Saturday, March 30, 2013

Morphology of Benign enlargement of prostate

Morphology of Benign enlargement of prostate
Morphology of BEP

Benign enlargement of prostate involves the hyperplasia of the prostatic epithelial and stromal cells which result into the development of large, slightly discrete nodules inside the periurethral area of the prostate.  When these cells are sufficiently enlarged, they force the nodules to exert pressure on the urethral canal causing slight, or at times complete urethra obstruction. This therefore may cause interference to the normal urine flow.

This condition results to symptoms such as frequent urination, painful urination (dysuria), urinary hesitancy, urinary tract infection risks and retention of urine. Although levels of specific prostate antigen can rise due to the increased volume of the organ as well as the inflammatory effects caused by the infections in the urinary tract, BPH does not increase the risks or lead to cancer.
In the actual sense, BPH is closely associated with hyperplasia (an increased level of cells) and not hypertrophy (an increase in the size of individual cells); however, it is common for the two terms to be used interchangeably among urologists. In addition, the growth of Adenomatous is believed to start at around the age of 30. It is approximated that 50% of men exhibit histological signs of BPH when they attain the age of 50 and 75% when they are 80 years of age and in about 40 to 50% of these men, the level of BPH is greatly pronounced.

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